Bladder cancerIntroduction

 Bladder cancer is a cancer often associated with chemical exposure through occupation, air pollution, smoking, and drinking water with contaminants.

Bladder cancer is a cancer often associated with chemical exposure through occupation, air pollution, smoking, and drinking water with contaminants.

Numerous ecological (geographical correlation) studies have found inverse correlations of bladder cancer incidence and/or mortality rates with solar ultraviolet-B (UVB) doses. The mechanisms whereby vitamin D reduces the risk of bladder cancer include effects on cellular differentiation and proliferation, angiogenesis around tumors, and metastasis.

Keeping serum 25-hydroxyvitamin D [25(OH)D] levels above 40 ng/mL to 60+ ng/mL should reduce the risk of bladder cancer incidence and increase survival odds.

Bladder cancer is a minor cancer affecting males in the United States about three times more frequently than females1. Risk factors for bladder cancer include chemicals such as those associated with tobacco23 and air pollution such as diesel exhaust or emissions from coal-fired power plants45 and chlorinated hydrocarbons from drinking water67.  Despite the general consensus that smoking is a risk factor, regions of the United States with high mortality rates of white male lung cancer in the period 1970-94 were regions of low bladder cancer mortality rates1. Perhaps smokers succumb to lung cancer before they could die from bladder cancer.

Page last edited: 22 August 2011

References

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  6. Cantor, K. P. Lynch, C. F. Hildesheim, M. E. Dosemeci, M. Lubin, J. Alavanja, M. Craun, G. Drinking water source and chlorination byproducts. I. Risk of bladder cancer. Epidemiology. 1998 Jan; 9 (1): 21-8.
  7. Morris, R. D. Audet, A. M. Angelillo, I. F. Chalmers, T. C. Mosteller, F. Chlorination, chlorination by-products, and cancer: a meta-analysis. Am J Public Health. 1992 Jul; 82 (7): 955-63.