Cervical cancerVitamin D levels

A study in Germany of cancer patients found “Seven patients with ovarian
carcinoma and 3 patients with cervix carcinoma were also examined. No less than 7 out of these 10 subjects displayed a plasma 25(OH)D concentration <20 μg/L with a mean value of 9.0 ±1.9 μg/L (n=7).”
1. This study also found that serum 25(OH)D level for those patients declined with age from a regression fit of 28 μg/l (ng/mL) at age 30 years to zero at 76 years. No separate information was given for cervical cancer.

A case-control study in Japan involving 405 incident cervical neoplasias (333 invasive carcinomas and 72 cervical intraepithelial neoplasias grade III [CIN3]) investigated the correlation of disease with respect to oral vitamin D and calcium intake2. For invasive cancer, there was a significantly reduced risk for > 291 international units (IU)/day vs < 162 IU/day (P-trend = 0.01). However, the effect was very strong for nonsmokers but not for smokers. A likely reason is that smokers have lower serum 25-hydroxyvitamin D [25(OH)D] levels than nonsmokers, evidently for similar oral intake and production from UVB irradiance3.

On the other hand, there was no effect of vitamin D intake on CIN3 for nonsmokers, but there was a significantly reduced risk for smokers (P-trend = 0.02)2.For those taking < 247 IU/day of vitamin D, higher calcium intake was associated with reduced risk of invasive cancer, but not for those taking > 247 IU/day.  

Page last edited: 22 August 2011


  1. Reinhold, U. Schmitz, B. Kurbacher, C. Nagel, W. Schmidt, M. Malaisse, W. J. Circulating 25-hydroxyvitamin D concentration in German cancer patients. Oncology reports. 2008 Dec; 20 (6): 1539-43.
  2. Hosono, S. Matsuo, K. Kajiyama, H. Hirose, K. Suzuki, T. Kawase, T. Kidokoro, K. Nakanishi, T. Hamajima, N. Kikkawa, F. Tajima, K. Tanaka, H. Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women. Eur J Clin Nutr. 2010 Apr; 64 (4): 400-9.
  3. Brot, C. Jorgensen, N. R. Sorensen, O. H. The influence of smoking on vitamin D status and calcium metabolism. Eur J Clin Nutr. 1999 Dec; 53 (12): 920-6.