Colorectal cancerHow does vitamin D work?

A number of mechanisms have been identified by which vitamin D reduces the risk of colorectal cancer. These include effects such as regulation of cell growth, differentiation, apoptosis (programmed death) and a wide range of cellular mechanisms central to the development of cancer12, regulation of calcium absorption and metabolism345, and prevention of epithelial cell disjunction6.

Details of how colon cancer cells convert circulating 25(OH)D to 1,25-dihydroxyvitamin D3 [1,25(OH)2D] including the effects of (phyto)estrogens is discussed in a recent paper7.

Page last edited: 23 August 2011

References

  1. Ingraham, B. A. Bragdon, B. Nohe, A. Molecular basis of the potential of vitamin D to prevent cancer. Curr Med Res Opin. 2008 Jan; 24 (1): 139-49.
  2. Rheem, D. S. Baylink, D. J. Olafsson, S. Jackson, C. S. Walter, M. H. Prevention of colorectal cancer with vitamin D. Scand J Gastroenterol. 2010 Aug; 45 (7-8): 775-84.
  3. Lamprecht, S. A. Lipkin, M. Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms. Nat Rev Cancer. 2003 Aug; 3 (8): 601-14.
  4. Peterlik, M. Cross, H. S. Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology. Eur J Clin Nutr. 2009 Sep 2;
  5. Peterlik, M. Grant, W. B. Cross, H. S. Calcium, vitamin D and cancer. Anticancer Res. 2009 Sep; 29 (9): 3687-98.
  6. Garland, C. F. Gorham, E. D. Mohr, S. B. Garland, F. C. Vitamin D for cancer prevention: global perspective. Ann Epidemiol. 2009 Jul; 19 (7): 468-83.
  7. Cross, H. S. Kallay, E. Regulation of the colonic vitamin D system for prevention of tumor progression: an update. Future Oncol. 2009 May; 5 (4): 493-507.