Endometrial cancerIntroduction

 Keeping serum 25-hydroxyvitamin D levels around 40 ng/mL might reduce risk by 25% and increase survival after diagnosis.

Endometrial cancer is one of the approximately 20 vitamin D-sensitive types of cancer. The evidence comes largely from ecological (geographical) studies of endometrial cancer mortality rates.

Calcium intake also seems to reduce risk123. Use of oral contraceptives reduces risk4, likely through mechanisms including reduction in inflammation5

Based on analogy with results for breast and colorectal cancer, it seems that keeping serum 25-hydroxyvitamin D levels above 40 ng/mL would reduce risk by 25% and increase survival after diagnosis.

Page last edited: 22 August 2011

References

  1. Salazar-Martinez, E. Lazcano-Ponce, E. Sanchez-Zamorano, L. M. Gonzalez-Lira, G. Escudero, D. E. Los Rios P. Hernandez-Avila, M. Dietary factors and endometrial cancer risk. Results of a case-control study in Mexico. Int J Gynecol Cancer. 2005 Sep-Oct; 15 (5): 938-45.
  2. McCullough, M. L. Bandera, E. V. Moore, D. F. Kushi, L. H. Vitamin D and calcium intake in relation to risk of endometrial cancer: a systematic review of the literature. Prev Med. 2008 Apr; 46 (4): 298-302.
  3. Peterlik, M. Grant, W. B. Cross, H. S. Calcium, vitamin D and cancer. Anticancer Res. 2009 Sep; 29 (9): 3687-98.
  4. Rice, L. W. Hormone prevention strategies for breast, endometrial and ovarian cancers. Gynecol Oncol. 2010 Aug 1; 118 (2): 202-7.
  5. Maia, H. J. Casoy, J. Non-contraceptive health benefits of oral contraceptives. Eur J Contracept Reprod Health Care. 2008 Mar; 13 (1): 17-24.