Endometrial cancerVitamin D levels

A study of prediagnostic serum 25(OH)D in a pooled analysis from case-control studies found no statistically significant variation from unity for any quintile1.

In a dietary intake case-control study in Mexico, high intake of vitamin D (OR, 0.38; 95% CI, 0.18-0.82, P= 0.003), and calcium (OR, 0.39; 95% CI, 0.17-0.89, P= 0.02) were inversely associated with endometrial cancer2. Two other case-control studies did not find statistically significant correlations with respect to oral vitamin D intake34. However, oral vitamin D intakes are often too low to have an effect on cancer risk.

A nested case-control study with data from seven cohort studies in the U.S. and China did not find any correlation between prediagnostic serum 25(OH)D and incidence of endometrial cancer. However, the mean follow-up time for the data in the study was 6.63 years. It has been found in other studies that such long follow-up times are unlikely to find a beneficial effect of vitamin D due to the long follow-up time56. Thus, this study does not contradict the UVB-vitamin D-cancer hypothesis.

Page last edited: 22 August 2011

References

  1. Zeleniuch-Jacquotte, A. Gallicchio, L. Hartmuller, V. Helzlsouer, K. J. McCullough, M. L. Setiawan, V. W. Shu, X. O. Weinstein, S. J. Weiss, J. M. Arslan, A. A. De Vivo, I. Gao, Y. T. Hayes, R. B. Henderson, B. E. Horst, R. L. Koenig, K. L. Patel, A. V. Purdue, M. P. Snyder, K. Steplowski, E. Yu, K. Zheng, W. Hankinson, S. E. Circulating 25-hydroxyvitamin D and risk of endometrial cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol. 2010 Jul 1; 172 (1): 36-46.
  2. Salazar-Martinez, E. Lazcano-Ponce, E. Sanchez-Zamorano, L. M. Gonzalez-Lira, G. Escudero, D. E. Los Rios P. Hernandez-Avila, M. Dietary factors and endometrial cancer risk. Results of a case-control study in Mexico. Int J Gynecol Cancer. 2005 Sep-Oct; 15 (5): 938-45.
  3. Barbone, F. Austin, H. Partridge, E. E. Diet and endometrial cancer: a case-control study. American journal of epidemiology. 1993 Feb 15; 137 (4): 393-403.
  4. Negri, E. La Vecchia, C. Franceschi, S. Levi, F. Parazzini, F. Intake of selected micronutrients and the risk of endometrial carcinoma. Cancer. 1996 Mar 1; 77 (5): 917-23.
  5. Lim, U. Freedman, D. M. Hollis, B. W. Horst, R. L. Purdue, M. P. Chatterjee, N. Weinstein, S. J. Morton, L. M. Schatzkin, A. Virtamo, J. Linet, M. S. Hartge, P. Albanes, D. A prospective investigation of serum 25-hydroxyvitamin D and risk of lymphoid cancers. Int J Cancer. 2009 Feb 15; 124 (4): 979-86.
  6. Grant, W. B. Effect of interval between serum draw and follow-up period on relative risk of cancer incidence with respect to 25-hydroxyvitamin D level; implications for meta-analyses and setting vitamin D guidelines. Dermato-endocrinology. 2011; 3 (3):