MelanomaTreatment

In view of its anti-cancer activity, Vitamin D is a potential treatment for melanoma.

A review concluded: “The possible results of high vitamin D levels on the immune system remain unclear however and a source of some concern, but the data support the view that serum levels in the range 70-100 nmol/L might be a reasonable target for melanoma patients as much as for other members of the population”1.

As discussed in other cancer documents, higher serum 25(OH)D levels (pre diagnosis and at diagnosis) have been found correlated with increased survival rates for those diagnosed with cancers such as breast, colorectal, lung and non-Hodgkin’s lymphoma.

However success of administration of vitamin D after diagnosis may be dependent on maintained vitamin D receptor expression in the malignant melanocytes23

Further work is necessary in this area.

Page last edited: 18 July 2011

References

  1. Field, S. Newton-Bishop, J. A. Melanoma and vitamin D. Molecular oncology. 2011 Apr; 5 (2): 197-214.
  2. Essa, S et al. VDR microRNA expression and epigenetic silencing of vitamin D signaling in melanoma cells. J Steroid Biochem Mol Biol. 2010 Jul; 121 (1-2): 110-3.
  3. Sertznig, P. et al. Peroxisome proliferator-activated receptor (PPAR) and vitamin D receptor (VDR) signaling pathways in melanoma cells: promising new therapeutic targets?. J Steroid Biochem Mol Biol. 2010 Jul; 121 (1-2): 383-6.