Multiple myeloma (MM) is considered incurable1. However, novel therapies are being sought to target a number of mechanisms associated with progression and metastasis of MM1. Vitamin D has a number of ways to combat some of these mechanisms such as its anti-angiogenesis and anti-metastasis actions2.
A study was conducted in Baltimore, Maryland on serum 25(OH)D levels of those diagnosed with MM and the effects of supplementation with vitamin D. While 40% had vitamin D deficiency [25(OH)D <15 ng/ml] and 25% had vitamin D sufficiency [25(OH)D >30 ng/ml], there were no correlations between serum 25(OH)D level and MM activity3. Beneficial effects of vitamin D supplementation were found for reducing muscle weakness, fatigue, and chronic bone pain in 10-20% of the patients.
A study of MM patients in Minnesota found: The prevalence of vitamin D deficiency increased in parallel with International Staging System (ISS): 16% of subjects in Stage I, 20% in Stage II, and 37% in Stage III (P = 0.03) were vitamin D deficient. No differences were detected between the two groups in terms of skeletal morbidity. Association of vitamin D deficiency with higher serum CRP, serum creatinine and ISS stage at time of diagnosis suggests that vitamin D deficiency may portend poorer outcomes in subjects with MM4.
Page last edited: 18 July 2011
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