Pancreatic cancerTreatment

There are no human trials of treating pancreatic cancer (PC) with vitamin D.

However, laboratory evidence suggests that it would be beneficial12.

There is evidence that higher serum 25(OH)D levels increase survival rates after diagnosis of PC.

African-Americans have a higher incidence rate for PC and an unexplained 42% increased risk of PC mortality rates than white Americans, and neither differences in smoking or obesity rates explained this disparity3. It was suggested that lower serum 25(OH)D levels for African-Americans compared to white Americans explains much of this difference4. It is not known why African-Americans have lower PC incidence rates.

Page last edited: 01 July 2011

References

  1. Schwartz, G. G. Eads, D. Rao, A. Cramer, S. D. Willingham, M. C. Chen, T. C. Jamieson, D. P. Wang, L. Burnstein, K. L. Holick, M. F. Koumenis, C. Pancreatic cancer cells express 25-hydroxyvitamin D-1 alpha-hydroxylase and their proliferation is inhibited by the prohormone 25-hydroxyvitamin D3. Carcinogenesis. 2004 Jun; 25 (6): 1015-26.
  2. Skinner, H. G. Vitamin D for the treatment and prevention of pancreatic cancer. Cancer Biol Ther. 2008 Mar; 7 (3): 437-9.
  3. Arnold LD, Patel AV, Yan Y, et al Are racial disparities in pancreatic cancer explained by smoking and overweight/obesity?. Cancer Epidemiol Biomarkers Prev. 2009; 18 (9): 2397–405.
  4. Grant, W. B. Relation between prediagnostic serum 25-hydroxyvitamin D level and incidence of breast, colorectal, and other cancers. J Photochem Photobiol B. 2010 May 12;