There are no human trials of treating pancreatic cancer (PC) with vitamin D.
There is evidence that higher serum 25(OH)D levels increase survival rates after diagnosis of PC.
African-Americans have a higher incidence rate for PC and an unexplained 42% increased risk of PC mortality rates than white Americans, and neither differences in smoking or obesity rates explained this disparity3. It was suggested that lower serum 25(OH)D levels for African-Americans compared to white Americans explains much of this difference4. It is not known why African-Americans have lower PC incidence rates.
Page last edited: 01 July 2011
- Schwartz, G. G. Eads, D. Rao, A. Cramer, S. D. Willingham, M. C. Chen, T. C. Jamieson, D. P. Wang, L. Burnstein, K. L. Holick, M. F. Koumenis, C. Pancreatic cancer cells express 25-hydroxyvitamin D-1 alpha-hydroxylase and their proliferation is inhibited by the prohormone 25-hydroxyvitamin D3. Carcinogenesis. 2004 Jun; 25 (6): 1015-26.
- Skinner, H. G. Vitamin D for the treatment and prevention of pancreatic cancer. Cancer Biol Ther. 2008 Mar; 7 (3): 437-9.
- Arnold LD, Patel AV, Yan Y, et al Are racial disparities in pancreatic cancer explained by smoking and overweight/obesity?. Cancer Epidemiol Biomarkers Prev. 2009; 18 (9): 2397–405.
- Grant, W. B. Relation between prediagnostic serum 25-hydroxyvitamin D level and incidence of breast, colorectal, and other cancers. J Photochem Photobiol B. 2010 May 12;