Sepsis and septicemiaPrevention

Those with sepsis in an intensive care unit had very low serum 25(OH)D levels.

Vitamin D has been found to reduce infection by a number of bacteria12.  

A study at Emory University found that patients with sepsis or in the intensive care unit of the hospital had much lower serum 25(OH)D levels than free living controls outside the hospital3.  Mean plasma LL-37 levels were significantly lower in critically ill subjects compared to healthy controls3.

Page last edited: 03 May 2011

References

  1. Gombart, A. F. The vitamin D-antimicrobial peptide pathway and its role in protection against infection. Future Microbiol. 2009 Nov; 41151-65.
  2. White, J. H. Vitamin D as an inducer of cathelicidin antimicrobial peptide expression: past, present and future. J Steroid Biochem Mol Biol. 2010 Mar; 121 (1-2): 234-8.
  3. Jeng, L. Yamshchikov, A. V. Judd, S. E. Blumberg, H. M. Martin, G. S. Ziegler, T. R. Tangpricha, V. Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. J Transl Med. 2009 Apr 23; 7 (1): 28.