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- How does vitamin D work?
- Vitamin D may help in multiple sclerosis by moderating the body’s immune response and by reducing the risk of Epstein Barr virus infection.
Th1 generate proinflammatory cytokines, which attack various self-tissues in the body leading to autoimmunity. Cytokines are small proteins that have an effect on cells. They include interleukins, lymphokines, tumor necrosis factor and the interferons which trigger inflammation and respond to infections.
It is also likely that vitamin D reduces the risk of EBV infection through production of antimicrobial compounds5, as it does for type A influenza6. There is good evidence that T regulatory cells are involved in both the innate and adaptive immune system including for EVB7 and that vitamin D affects T regulatory cell function849.
Page last edited: 03 May 2011
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- Smolders, J. Menheere, P. Thewissen, M. Peelen, E. Tervaert, J. W. Hupperts, R. Damoiseaux, J. Regulatory T cell function correlates with serum 25-hydroxyvitamin D, but not with 1,25-dihydroxyvitamin D, parathyroid hormone and calcium levels in patients with relapsing remitting multiple sclerosis. J Steroid Biochem Mol Biol. 2010 Jul; 121 (1-2): 243-6.
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- Handel, A. E. Handunnetthi, L. Giovannoni, G. Ebers, G. C. Ramagopalan, S. V. Genetic and environmental factors and the distribution of multiple sclerosis in Europe. Eur J Neurol. 2010 Sep; 17 (9): 1210-4.