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A study of Parkinson’s disease (PD) patients in the southeastern U.S. found the following:
Significantly more patients with PD (55%) had insufficient vitamin D than did controls (36%) or patients with AD (41%; P = 0.02, chi(2)test). The mean (SD) 25(OH)D concentration in the PD cohort was significantly lower than in the AD and control cohorts (31.9 [13.6] ng/mL vs 34.8 [15.4] ng/mL and 37.0 [14.5] ng/mL, respectively; P = 0.03)1.
However, in a study such as this, it is not clear whether the disease condition contributed to the serum 25(OH)D status.
In a study in Finland:
During the 29-year follow-up period, 50 incident Parkinson disease cases occurred. Serum 25-hydroxyvitamin D level was determined from frozen samples stored at baseline. Estimates of the relationship between serum vitamin D concentration and Parkinson disease incidence were calculated using the Cox model. Individuals with higher serum vitamin D concentrations showed a reduced risk of Parkinson disease. The relative risk between the highest and lowest quartiles was 0.33 (95% confidence interval, 0.14-0.80) after adjustment for sex, age, marital status, education, alcohol consumption, leisure-time physical activity, smoking, body mass index, and month of blood draw2.
Page last edited: 03 May 2011
- Evatt, M. L. Delong, M. R. Khazai, N. Rosen, A. Triche, S. Tangpricha, V. Prevalence of vitamin d insufficiency in patients with Parkinson disease and Alzheimer disease. Arch Neurol. 2008 Oct; 65 (10): 1348-52.
- Knekt, P. Kilkkinen, A. Rissanen, H. Marniemi, J. Saaksjarvi, K. Heliovaara, M. Serum vitamin D and the risk of Parkinson disease. Arch Neurol. 2010 Jul; 67 (7): 808-11.
- Invernizzi, M. Carda, S. Viscontini, G. S. Cisari, C. Osteoporosis in Parkinson’s disease. Parkinsonism Relat Disord. 2009 Jun; 15 (5): 339-46.
- Sato, Y. Kikuyama, M. Oizumi, K. High prevalence of vitamin D deficiency and reduced bone mass in Parkinson’s disease. Neurology. 1997 Nov; 49 (5): 1273-8.
- Sato, Y. Manabe, S. Kuno, H. Oizumi, K. Amelioration of osteopenia and hypovitaminosis D by 1alpha-hydroxyvitamin D3 in elderly patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1999 Jan; 66 (1): 64-8.
- Sato, Y. Kaji, M. Tsuru, T. Satoh, K. Kondo, I. Vitamin K deficiency and osteopenia in vitamin D-deficient elderly women with Parkinson’s disease. Arch Phys Med Rehabil. 2002 Jan; 83 (1): 86-91.
- Sato, Y. Honda, Y. Iwamoto, J. Kanoko, T. Satoh, K. Abnormal bone and calcium metabolism in immobilized Parkinson’s disease patients. Mov Disord. 2005 Dec; 20 (12): 1598-603.
- Sato, Y. Iwamoto, J. Kanoko, T. Satoh, K. Alendronate and vitamin D2 for prevention of hip fracture in Parkinson’s disease: a randomized controlled trial. Mov Disord. 2006 Jul; 21 (7): 924-9.
- Sato, Y. Honda, Y. Iwamoto, J. Risedronate and ergocalciferol prevent hip fracture in elderly men with Parkinson disease. Neurology. 2007 Mar 20; 68 (12): 911-5.